2.

Microwave-assisted synthesis of 1,2-benzisoxazole derivatives in ionic liquid

Kiran F. Shelke, Suryakant B. Sapkal, Nana V. Shitole, Bapurao B. Shingate, Murlidhar S. Shingare

Org. Commun. (2009), 2:3 ; 72-78

Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, (MS), India

Abstract: A simple, highly efficient and environmentally benign method for the efficient conversion of 2-hydroxyalkyl/aryl ketoximes to 1,2-benzisoxazoles in the presence of catalytic amount of basic ionic liquid 1-butyl-3-methylimidazolium hydroxide ([bmim]OH) carried out under the influence of microwave irradiation. This method gives remarkable advantages such as short reaction times (30-60 sec), simple work-up procedure and excellent yields (85-96%). The ionic liquid was successfully reused for four cycles without significant loss of activity.

Keywords: 1,2-Benzisoxazole ketoxime; ionic liquid; microwave irradiation.